Table 3. Association between menstrual cycle irregularity1 and ovarian cancer stratified by oral contraceptive use in the New England Case-Control Study, 1992-2008.
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|---|---|---|---|---|
| Oral Contraceptive use | ||||
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| Never | <5 years | ≥5 years | Pinteraction | |
| N (cases/controls) | 974/766 | 663/703 | 404/631 | |
| Overall2 | 1.21 (0.82-1.77) | 0.60 (0.41-0.90) | 0.90 (0.56-1.44) | 0.001 |
| High grade serous invasive2 | 0.92 (0.56-1.51) | 0.47 (0.25-0.89) | 0.71 (0.33-1.50) | 0.06 |
| Serous borderline2 | 3.48 (1.85-6.56) | 0.49 (0.20-1.20) | 1.14 (0.44-2.91) | 0.0003 |
1
If periods were reported as never becoming regular.
2
Models adjusted for age, center, study, parity, tubal ligation, and family history of ovarian cancer.