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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Neurobiol Aging. 2017 Jun 3;57:170–177. doi: 10.1016/j.neurobiolaging.2017.05.020

Table 1.

Top piRNAs significantly differentially expressed between AD cases and controls

piRNA Alias length (nt) Chr Normalized intensity AD vs. Control Brain vs. Stomach Gene
AD Control FC p FC p
With top intensities in AD (intensities>12)
DQ571030 piR-hsa-1281 29 chr19 29291.9 15703.3 1.9 ↑ 0.024 17.1 ↑ 2.2×10−6 C19orf18 B
DQ571029 piR-hsa-1280 27 chr19 28564.7 16838.6 1.7 ↑ 0.031 14.6 ↑ 4.5×10−7 C19orf18 B
DQ571031 piR-hsa-1282 32 chr19 20583.6 11557.8 1.8 ↑ 0.049 18.8 ↑ 7.6×10−6 C19orf18 B
DQ597217 piR-hsa-27492 28 chr11 24283.1 13388.0 1.8 ↑ 0.042 17.6 ↑ 7.3×10−7 GALNT18 B
DQ597216 piR-hsa-27491 26 chr11 24078.7 12986.4 1.9 ↑ 0.037 14.9 ↑ 8.1×10−8 GALNT18 B
DQ597479 piR-hsa-27725 28 chr3 11637.5 5522.6 2.1 ↑ 0.020 14.0 ↑ 1.9×10−6 ANKRD28 B
DQ585095 piR-hsa-15406 30 chr1 9853.0 6558.0 1.5 ↑ 0.032 3.9 ↑ 5.8×10−4 ATAD3B B
DQ576872 piR-hsa-7193 31 chr2 7703.6 3777.0 2.0 ↑ 0.034 6.8 ↑ 2.2×10−5 DOCK10 B
DQ571243 piR-hsa-1580 29 chr11 9655.2 5028.9 1.9 ↑ 0.042 7.0 ↑ 8.7×10−6 to C11orf87 B
DQ597973 piR-hsa-28188 27 chr11 9039.6 4490.8 2.0 ↑ 0.027 7.2 ↑ 3.5×10−6 to C11orf87 B
DQ597974 piR-hsa-28189 28 chr11 8107.7 4113.4 2.0 ↑ 0.031 7.6 ↑ 6.6×10−6 to C11orf87 B
DQ597972 piR-hsa-28187 26 chr11 5615.2 2771.6 2.0 ↑ 0.020 6.5 ↑ 6.1×10−6 to C11orf87 B
With top FC↑ between cases and controls (FC≥2)
DQ576492 piR-hsa-6740 30 chr10 19.0 7.8 2.4 ↑ 0.021 1.1 ↑ 0.809 LINC00837
DQ590835 piR-hsa-21131 28 chr9 210.9 89.0 2.4 ↑ 0.030 5.5 ↑ 3.2×10−5 PTPRD B
DQ574023 piR-hsa-4300 26 chr13 18.7 7.9 2.4 ↑ 0.029 1.1 ↑ 0.675 B3GALTL B
DQ599205 piR-hsa-29476 26 chr1 48.0 22.1 2.2 ↑ 0.004 1.2 ↑ 0.753 KIAA0319L B
DQ598028 piR-hsa-28243 29 chr19 37.0 17.1 2.2 ↑ 0.018 1.7 ↓ 0.468 FLJ25328
DQ573352 piR-hsa-3645 26 chr7 34.4 16.3 2.1 ↑ 0.037 1.1 ↓ 0.884 ABCA13 B
DQ581610 piR-hsa-11139 29 chr17 23.1 10.9 2.1 ↑ 0.019 “Brain” - to EVPLL
DQ599207 piR-hsa-29478 29 chr22 65.6 31.5 2.1 ↑ 0.018 1.6 ↑ 0.215 to ELFN2 B
DQ597479* piR-hsa-27725 28 chr3 11637.5 5522.6 2.1 ↑ 0.020 14.0 ↑ 1.9×10−6 ANKRD28 B
DQ597973* piR-hsa-28188 27 chr11 9039.6 4490.8 2.0 ↑ 0.027 7.2 ↑ 3.5×10−6 to C11orf87 B
DQ597974* piR-hsa-28189 28 chr11 8107.7 4113.4 2.0 ↑ 0.031 7.6 ↑ 6.6×10−6 to C11orf87 B
DQ597972* piR-hsa-28187 26 chr11 5615.2 2771.6 2.0 ↑ 0.020 6.5 ↑ 6.1×10−6 to C11orf87 B
DQ576872* piR-hsa-7193 31 chr2 7703.6 3777.0 2.0 ↑ 0.034 6.8 ↑ 2.2×10−5 DOCK10 B
With top FC ↓ between cases and controls (FC≥2)
DQ579851 piR-hsa-10106 32 chr15 10.8 27.0 2.5 ↓ 0.025 2.1 ↑ 0.050 to PGPEP1L
DQ600318 piR-hsa-30518 26 chr17 14.0 34.7 2.5 ↓ 0.010 “Brain” - LRRC37A3 B
DQ571669 piR-hsa-1963 30 chr17 14.8 34.6 2.3 ↓ 0.025 “Brain” - VPS53 B
DQ586404 piR-hsa-16724 29 chr18 15.7 33.3 2.1 ↓ 0.006 1.6 ↑ 0.234 to GNAL B
With lowest p values between cases and controls and FC↑ (p≤0.010)
DQ591371 piR-hsa-21636 28 chr1 42.7 27.5 1.6 ↑ 0.002 2.0 ↑ 0.012 to NBPF4
DQ580484 piR-hsa-10710 30 chr1 17.6 9.0 1.9 ↑ 0.002 1.2 ↑ 0.448 to TDRD5
DQ577835 piR-hsa-8094 30 chr9 40.4 23.0 1.8 ↑ 0.003 1.5 ↑ 0.055 FAM225B
DQ586113 piR-hsa-16363 29 chr17 12.9 7.5 1.7 ↑ 0.003 “Brain” - to EVPLL
DQ599205* piR-hsa-29476 26 chr1 48.0 22.1 2.2 ↑ 0.004 1.2 ↑ 0.753 KIAA0319L B
DQ580261 piR-hsa-10501 28 chr10 350.2 233.2 1.5 ↑ 0.005 3.3 ↑ 7.6×10−4 NRG3 B
DQ597396 piR-hsa-27133 29 chr11 599.6 346.4 1.7 ↑ 0.007 1.4 ↑ 0.045 to UBASH3B B
DQ597397 piR-hsa-27134 31 chr11 863.9 545.2 1.6 ↑ 0.010 1.6 ↑ 0.011 to UBASH3B B
With lowest p values between cases and controls and FC ↓ (p≤0.002)
DQ575353 piR-hsa-5645 28 chr17 19.0 28.6 1.5 ↓ 0.002 2.2 ↑ 1.0×10−3 LRRC37A B
DQ577904 piR-hsa-8163 30 chr1 12.0 18.3 1.5 ↓ 0.005 2.0 ↑ 0.101 to RABGEF1 B
DQ595753 piR-hsa-25985 29 chr1 11.1 19.9 1.8 ↓ 0.005 “Brain” - SCP2 B
DQ586404* piR-hsa-16724 29 chr18 15.7 33.3 2.1 ↓ 0.006 1.6 ↑ 0.234 to GNAL B
DQ579582 piR-hsa-9851 31 chr22 60.7 91.0 1.5 ↓ 0.006 2.2 ↑ 0.012 POM121L8P
DQ584325 piR-hsa-14547 27 chr15 13.0 21.5 1.7 ↓ 0.009 1.9 ↑ 0.011 to C2CD4B
With locations at or close to AD-related genes
DQ583613 piR-hsa-13893 29 chr6 3694.9 2295.2 1.6 ↑ 0.038 4.2 ↑ 2.3×10−4 to HIST1H4H B
DQ584879 piR-hsa-14621 28 chr15 13.4 8.7 1.5 ↑ 0.011 “Brain” - CYP19A1 B
DQ597214 piR-hsa-27489 27 chr3 117.0 61.7 1.9 ↑ 0.025 3.4 ↑ 9.9×10−3 to PLCH1 B
DQ583911 piR-hsa-14148 30 chr6 16.3 9.5 1.7 ↑ 0.040 “Brain” - to CCR6 B
DQ599147 piR-hsa-29114 31 chr17 699.9 386.3 1.8 ↑ 0.048 3.1 ↑ 1.7×10−3 CTC1 B
DQ600513 piR-hsa-30713 28 chr10 311.9 182.1 1.7 ↑ 0.014 3.5 ↑ 5.1×10−4 DOCK1 B
DQ575353 piR-hsa-5645 28 chr17 19.0 28.6 1.5 ↓ 0.002 2.2 ↑ 1.0×10−3 LRRC37A B
DQ575681 piR-hsa-5959 28 chr11 31.8 47.9 1.5 ↓ 0.029 “Brain” - BACE1 B
DQ574452 piR-hsa-4685 30 chr14 9.0 13.8 1.5 ↓ 0.040 “Brain” - to KCNK10 B
DQ596958 piR-hsa-27248 30 chr15 14.0 21.3 1.5 ↓ 0.039 “Brain” - CYP19A1 B
B

These genes are expressed in brain; chr, chromosome;

↑, up-regulated; ↓, down-regulated; “Brain”, brain-specific expression in constrast to stomach. FC, fold-changes; p, p values from t-test; AD, Alzheimer’s disease; “to”, proximate to.

*

appears at least twice in this table.