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. Author manuscript; available in PMC: 2017 Aug 3.
Published in final edited form as: Basic Res Cardiol. 2016 Apr 4;111(3):29. doi: 10.1007/s00395-016-0547-4

Fig. 3.

Fig. 3

Relationship between cardiac work and myocardial blood flow during stress with NE (NE 2.5–5.0–7.5–10 µg/kg/min). MBF values at baseline are comparable in the four groups (N = 10 per group). The relation between myocardial blood flow and the double product in ZLN was significantly greater than in the ZOF (P <0.05). The induction of mt-DNA damage in ZLN resulted in a significant impairment of the blood flow-double product relationship (ZLN vs. ZLN + mt-tat-ExoIII, P <0.05) Repair of mtDNA damage in ZOF (ZOF + mt-tat-EndoIII) significantly increased the flow-double product relationship compared to ZOF (P < 0.05) and rendered this relationship not different from untreated ZLN (ZLN + mt-tat-ExoIII vs. ZOF, P = NS). N = 7–10 per group