Fig. 4.
Immunostaining of myocardial sections for Hypoxyprobe after cardiac stress with norepinephrine. Note the presence of areas of hypoxia (white arrows) in ZOF, ZLN + mt-tat-ExoIII groups (b, c). Repair of mitochondrial DNA damage attenuated the development of hypoxic regions in the group ZOF + mt-tat-EndoIII (d). ZLN (a) did not exhibit a clear hypoxic signal, as evidenced by the absence of fluorescence. N = 1 per group