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. Author manuscript; available in PMC: 2017 Aug 3.
Published in final edited form as: Basic Res Cardiol. 2016 Apr 4;111(3):29. doi: 10.1007/s00395-016-0547-4

Fig. 6.

Fig. 6

Assessment of the vasodilator response of arterioles isolated from Zucker lean rats (N = 8) (ZLN-Art) to conditioned buffer (CB) from the four groups: ZLN, ZOF, ZLN + mt-tat-ExoIII, and ZOF + mt-tat-EndoIII (N = 8, each group). Dilation to ZLN-CB revealed two components: catalase-inhibited and purinergic component blocked by 8-pSPT (a). Catalase inhibited the dilator response of 60–70 % and the use of the A1 purinergic receptor antagonist completely blocked the remaining response. The dilation to ZOF-CB was completely inhibited by catalase and the purinergic component was absent (b). In ZLN + mt-tat-ExoIII-CB, the response was inhibited by catalase (d); whereas in ZOF + mt-tat-EndoIII-CB the purinergic component re-emerged and the dilation was attributed to a catalase-inhibited component and a purinergic component (c). N = 7–9 per group/treatment