. 2017 Jul 31;13:1744806917720336. doi: 10.1177/1744806917720336

Table 1.

Effects of CNT on ROS and ATP in brain tissue of mice.

Groups	Corpus striatum		Spinal cord		Hippocampus
Groups	ROS (Y/mg protein)	ATP (µmol/mg protein)	ROS (Y/mg protein)	ATP (µmol/mg protein)	ROS (Y/mg protein)	ATP (µmol/mg protein)
Normal saline	96 ± 9^a	861 ± 62^a	87 ± 8^a	376 ± 32^a	78 ± 9^a	436 ± 40^a
Sham	116 ± 12^a	747 ± 68^a	127 ± 14^a	361 ± 29^a	108 ± 11^a	397 ± 35^a
Injury	239 ± 20	308 ± 26	224 ± 21	69 ± 7	250 ± 20	64 ± 8
CNT LD	136 ± 16^a	660 ± 79^a,	164 ± 17^a	282 ± 13^a	162 ± 18^a	305 ± 35^a
CNT LD+DPCPX	222 ± 29^b	358 ± 39^b	218 ± 19^b	124 ± 16^a,b	234 ± 22^b	130 ± 16^a,b
CNT LD+ZM241385	152 ± 16^a	625 ± 78^a	180 ± 19^a	259 ± 31^a	175 ± 19^a	277 ± 32^a
CNT HD	187 ± 17^a	465 ± 56^a	191 ± 17^a	191 ± 17^a	190 ± 17^a	226 ± 13^a
CNT HD+DPCPX	202 ± 19	321 ± 21^b	214 ± 17	113 ± 8^a,b	235 ± 31^b	183 ± 19^a,b
CNT HD+ZM241385	134 ± 16^a,b	708 ± 72^a,b	155 ± 18^a,b	378 ± 39^a,b	153 ± 20^a,b	315 ± 30^a,b

Mice groups of CNT LD and HD received 25 µg/kg and 100 µg/kg i.p., respectively; 1 h later after administration of CNT, mice in CNT+DPCPX or CNT+ZM241385 groups were intraperitoneally injected with DPCPX (2 mg/kg) or ZM241385 (1 mg/kg). Data were represented as $\bar{x} \pm s$ , n = 8. a, p < 0.05 as compared to compression injury group; b, p < 0.05 as compared to CNT group at corresponding dose.

CNT: cobra neurotoxin; LD: low dose; HD: high dose.