Table 2. Summary ORs and 95% CI of lncRNA H19 polymorphisms and cancer risk.
| Locus | N* | No. of case/control | OR | 95% CI | P | I2 (%)a | OR | 95% CI | P | I2 (%)a | OR | 95% CI | P | I2 (%)a | OR | 95% CI | P | I2 (%)a | OR | 95% CI | P | I2 (%)a | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs2839698 G>A | A vs. G | GA vs. GG | AA vs. GG | GA+AA vs. GG | AA vs. GG+GA | |||||||||||||||||||||
| Total | 5 | 3369/3510 | 1.08 | 0.96-1.23 | 0.21 | 58.8 | 1.06 | 0.91-1.23 | 0.44 | 43.8 | 1.15 | 0.83-1.58 | 0.42 | 66.1 | 1.08 | 0.94-1.25 | 0.27 | 46.5 | 1.15 | 1.85-1.57 | 0.36 | 67.4 | ||||
| Ethnicity | ||||||||||||||||||||||||||
| Asian | 4 | 3192/3306 | 1.09 | 0.94-1.27 | 0.24 | 68.6 | 1.09 | 0.98-1.21 | 0.10 | 0 | 1.15 | 0.78-1.69 | 0.48 | 74.4 | 1.12 | 0.97-1.28 | 0.11 | 42.3 | 1.10 | 0.76-1.59 | 0.63 | 74.0 | ||||
| Design | ||||||||||||||||||||||||||
| PB | 2 | 1324/1407 | 1.17 | 1.04-1.31 | 0.01 | 0 | 0.91 | 0.53-1.55 | 0.72 | 78.2 | 1.43 | 1.08-1.88 | 0.01 | 10.9 | 1.02 | 0.68-1.54 | 0.93 | 68.2 | 1.46 | 1.13-1.89 | <0.01 | 0 | ||||
| HB | 3 | 2045/2103 | 1.05 | 0.86-1.28 | 0.63 | 69.8 | 1.08 | 0.92-1.26 | 0.36 | 20.6 | 1.02 | 0.62-1.67 | 0.93 | 74.7 | 1.08 | 0.90-1.31 | 0.40 | 47.6 | 0.98 | 0.61-1.57 | 0.92 | 75.0 | ||||
| Type | ||||||||||||||||||||||||||
| Bladder cancer | 2 | 1226/1601 | 1.00 | 0.89-1.12 | 1.00 | 0 | 0.85 | 0.59-1.24 | 0.41 | 58.0 | 1.03 | 0.79-1.36 | 0.82 | 0 | 0.96 | 0.82-1.11 | 0.57 | 0 | 1.13 | 0.88-1.46 | 0.35 | 28.0 | ||||
| Digestive cancer | 2 | 1647/1703 | 1.23 | 1.10-1.36 | <0.01 | 0 | 1.17 | 1.02-1.35 | 0.03 | 0 | 1.58 | 1.22-2.05 | <0.01 | 0 | 1.23 | 1.08-1.41 | <0.01 | 0 | 1.48 | 1.15-1.90 | <0.01 | 0 | ||||
| rs217727 G>A | A vs. G | GA vs. GG | AA vs. GG | GA+AA vs. GG | AA vs. GG+GA | |||||||||||||||||||||
| Total | 5 | 3334/3768 | 1.01 | 0.88-1.07 | 0.86 | 72.6 | 0.88 | 0.73-1.06 | 0.18 | 65.0 | 0.60 | 0.26-1.39 | 0.23 | 16.0 | 0.94 | 0.78-1.12 | 0.47 | 66.3 | 1.19 | 0.93-1.53 | 0.16 | 64.9 | ||||
| Ethnicity | ||||||||||||||||||||||||||
| Asian | 4 | 3157/3564 | 1.05 | 0.91-1.21 | 0.49 | 73.6 | 0.90 | 0.73-1.11 | 0.32 | 71.9 | 0.50 | 0.20-1.25 | 0.14 | 23.3 | 0.97 | 0.80-1.17 | 0.76 | 70.3 | 1.23 | 0.97-1.57 | 0.09 | 68.0 | ||||
| Design | ||||||||||||||||||||||||||
| PB | 3 | 1788/1874 | 0.92 | 0.84-1.01 | 0.09 | 46.6 | 0.79 | 0.69-0.91 | <0.01 | 26.6 | 1.07 | 0.36-3.22 | 0.90 | 0 | 0.82 | 0.72-0.94 | <0.01 | 0 | 1.03 | 0.66-1.58 | 0.91 | 73.5 | ||||
| HB | 2 | 1546/1894 | 1.15 | 0.97-1.37 | 0.12 | 62.9 | 1.06 | 0.80-1.40 | 0.70 | 67.3 | 0.26 | 0.06-1.20 | 0.08 | 31.5 | 1.13 | 0.85-1.51 | 0.39 | 71.6 | 1.36 | 1.12-1.66 | <0.01 | 0 | ||||
| Type | ||||||||||||||||||||||||||
| Bladder cancer | 2 | 1223/1598 | 0.92 | 0.65-1.31 | 0.65 | 73.4 | 0.90 | 0.77-1.06 | 0.22 | 0 | 0.51 | 0.04-6.77 | 0.61 | 62.5 | 0.89 | 0.66-1.21 | 0.47 | 53.5 | 0.97 | 0.41-2.32 | 0.95 | 58.0 | ||||
| Digestive cancer | 2 | 1647/1703 | 1.06 | 0.75-1.50 | 0.75 | 90.5 | 1.02 | 0.71-1.47 | 0.93 | 80.4 | 0.52 | 0.10-2.81 | 0.45 | 0 | 1.05 | 0.67-1.64 | 0.82 | 88.0 | 1.13 | 0.69-1.85 | 0.63 | 82.1 | ||||
| rs2107425 C>T | T vs. C | CT vs. CC | TT vs. CC | CT+TT vs. CC | TT vs. CC+CT | |||||||||||||||||||||
| Total | 8 | 10946/15612 | 0.94 | 0.86-1.01 | 0.09 | 60.8 | 0.88 | 0.77-1.00 | 0.05 | 70.4 | 0.97 | 0.89-1.06 | 0.51 | 32.4 | 0.87 | 0.78-0.97 | 0.02 | 68.4 | 1.02 | 0.94-1.11 | 0.60 | 0 | ||||
| Ethnicity | ||||||||||||||||||||||||||
| Caucasian | 6 | 9730/14751 | 0.90 | 0.84-0.97 | 0.01 | 51.8 | 0.82 | 0.72-0.94 | <0.01 | 69.1 | 0.94 | 0.86-1.04 | 0.22 | 13.9 | 0.83 | 0.75-0.92 | <0.01 | 62.9 | 1.01 | 0.92-1.10 | 0.85 | 8.1 | ||||
| Design | ||||||||||||||||||||||||||
| PB | 7 | 10467/15409 | 0.93 | 0.85-1.01 | 0.09 | 66.7 | 0.86 | 0.75-0.99 | 0.03 | 73.9 | 0.95 | 0.83-1.10 | 0.50 | 43.6 | 0.86 | 0.77-0.97 | 0.01 | 71.7 | 1.02 | 0.94-1.11 | 0.57 | 6.5 | ||||
| Type | ||||||||||||||||||||||||||
| breast cancer | 4 | 3464/4204 | 0.95 | 0.80-1.13 | 0.57 | 77.7 | 0.94 | 0.75-1.19 | 0.62 | 73.2% | 0.94 | 0.67-1.31 | 0.72 | 73.0 | 0.89 | 0.74-1.08 | 0.24 | 73.3 | 0.95 | 0.76-1.20 | 0.68 | 51.8 | ||||
| Ovarian cancer | 2 | 6826/11001 | 0.92 | 0.80-1.05 | 0.20 | 82.5 | 0.82 | 0.65-1.05 | 0.10 | 89.2 | 0.98 | 0.89-1.09 | 0.74 | 18.4 | 0.84 | 0.68-1.05 | 0.13 | 88.6 | 1.05 | 0.95-1.16 | 0.37 | 0.0 | ||||
* Numbers of comparisons.
a Test for heterogeneity.
PB: Population-based HB: Hospital-based.
RT-PCR: Real-time PCR