Table 3. Comparison of adverse events between the chemotherapy+CIK/DC-CIK and chemotherapy alone groups.

Adverse events	Chemo+CIK/DC-CIK	Chemo	Analysis method	Heterogeneity		Odds Ratio (OR)	95% CI	P-value
	No. patients (n)	No. patients (n)		I2 (%)	P-value
Leucopenia	412	384	Random	38	0.15	0.51	0.32 to 0.82	0.005
Leucopenia I	339	312	Random	0	0.48	1.02	0.67 to 1.56	0.92
Leucopenia II	339	312	Random	63	0.05	0.81	0.42 to 1.56	0.53
Leucopenia III	339	312	Random	23	0.28	0.40	0.21 to 0.75	0.004
Leucopenia IV	339	312	Random	0	1.00	0.55	0.26 to 1.19	0.13
Anemia	382	354	Random	75	0.003	0.52	0.26 to 1.05	0.07
Anemia I	339	312	Random	59	0.06	0.52	0.27 to 1.00	0.05
Anemia II	339	312	Random	0	0.55	0.71	0.44 to 1.14	0.15
Anemia III	339	312	Random	0	0.53	0.60	0.22 to 1.63	0.32
Anemia IV	339	312	Random	0	0.68	0.45	0.13 to 1.51	0.19
Thrombocytopenia	412	384	Random	63	0.02	0.54	0.29 to 0.99	0.05
Thrombocytopenia I	339	312	Random	23	0.27	0.69	0.42 to 1.13	0.14
Thrombocytopenia II	339	312	Random	55	0.08	0.76	0.35 to 1.69	0.50
Thrombocytopenia III	339	312	Random	0	0.96	0.24	0.10 to 0.54	0.0006
Thrombocytopenia IV	339	312	Random	0	0.88	0.90	0.22 to 3.63	0.88
Nausea, vomiting	427	399	Random	65	0.009	0.55	0.31 to 0.98	0.04
Nausea, vomiting I	339	312	Random	67	0.03	1.06	0.49 to 2.29	0.88
Nausea, vomiting II	339	312	Random	0	0.86	0.61	0.42 to 0.89	0.01
Nausea, vomiting III	339	312	Random	0	0.57	0.48	0.21 to 1.08	0.08
Nausea, vomiting IV	339	312	Random	0	1.00	0.45	0.08 to 2.45	0.35
Liver dysfunction	401	374	Random	0	0.44	0.55	0.38 to 0.80	0.002
Liver dysfunction I	298	272	Fixed	0	0.96	0.59	0.33 to 1.06	0.08
Liver dysfunction II	298	272	Fixed	0	0.57	0.52	0.31 to 0.88	0.01
Liver dysfunction III	298	272	Fixed	36	0.21	0.90	0.26 to 3.14	0.87
Liver dysfunction IV	298	272	Fixed	0	0.47	0.53	0.13 to 2.26	0.39
Myelosuppression	159	159	Random	0	0.90	0.21	0.11 to 0.39	< 0.00001
Peripheral neurotoxicity	196	195	Random	0	0.42	0.31	0.18 to 0.55	< 0.00001
Gastrointestinal AE	153	152	Random	0	0.53	0.26	0.15 to 0.45	< 0.00001

AE: adverse reaction.