Table 4. Meta-analysis of OS, DFS, ORR and DCR in Chemo-DC-CIK and Chemo-CIK subgroups.

Immunotherapy type (subgroup)	Parameters	Chemo+CIK/DC-CIK	Chemo	Analysis method	Heterogeneity		Odds Ratio (OR)	95% CI	P-value
		No. patients (n)	No. patients (n)		I2 (%)	P-value
DC-CIK	1-year OS	273	313	Fixed	0	0.94	2.02	1.05 to 3.89	0.04
	2-year OS	270	317	Fixed	0	0.90	2.43	1.55 to 3.83	0.0001
	3-year OS	151	192	Fixed	26	0.25	2.73	1.64 to 4.55	0.0001
	1-year DFS	106	147	Fixed	0	0.60	4.54	2.26 to 9.11	< 0.0001
	2-year DFS	92	133	Fixed	0	0.98	2.45	1.40 to 4.28	0.002
	3-year DFS	106	147	Fixed	50	0.13	2.41	1.43 to 4.08	0.001
	ORR	547	539	Fixed	0	0.99	1.85	1.44 to 2.37	< 0.00001
	DCR	547	539	Fixed	0	0.94	2.94	2.20 to 3.93	< 0.00001
CIK	1-year OS	290	280	Fixed	20	0.29	2.36	1.44 to 3.86	0.0006
	2-year OS	209	200	Fixed	35	0.21	2.78	1.70 to 4.54	< 0.0001
	3-year OS	206	198	Fixed	0	0.83	2.37	1.53 to 3.65	0.0001
	1-year DFS	105	97	Fixed	0	0.35	3.17	1.59 to 6.33	0.001
	2-year DFS	105	97	Fixed	0	0.63	2.51	1.41 to 4.46	0.002
	3-year DFS	105	97	Fixed	0	1.00	1.98	1.11 to 3.52	0.02
	ORR	223	218	Fixed	0	0.53	1.79	1.16 to 2.78	0.009
	DCR	223	218	Fixed	0	0.64	2.33	1.37 to 3.97	0.002