Table 2. The seven SNPs significantly (P < 1.21 × 10−6) associated with the serum concentration of creatinine in the EWAS.
| Gene | dbSNP | Nucleotide (amino acid) substitutiona | Chromosome: position | MAF (%) | P (genotype) |
|---|---|---|---|---|---|
| CAT | rs139421991 | G/A (R320Q) | 11: 34456720 | 0.3 | 6.34 × 10−11 |
| EIF2AK4 | rs35602605 | G/T (G1306C) | 15: 40016658 | 0.1 | 1.60 × 10−10 |
| SP7 | rs188929035 | G/A (A5V) | 12: 53329374 | 0.4 | 7.10 × 10−9 |
| CSMD2 | rs148658404 | G/A (S3311F) | 1: 33533855 | 0.7 | 3.89 × 10−7 |
| SASH1 | rs199980930 | G/A | 6: 148546146 | 0.1 | 4.57 × 10−7 |
| RNF123 | rs35620248 | G/A (R387Q) | 3: 49700521 | 0.3 | 1.20 × 10−6 |
| ALG12 | rs3922872 | T/C (I393V) | 22: 49904240 | 5.5 | 1.20 × 10−6 |
The relation of genotypes of SNPs to the serum concentration of creatinine was evaluated by linear regression analysis. aMajor allele/minor allele.