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. 2017 Apr 3;8(28):45286–45297. doi: 10.18632/oncotarget.16787

Figure 4. Location of TIAM1 variants.

Figure 4

Variants are mapped to specific amino acids on the TIAM1 linearized protein model. The specific domains are indicated (from the N-terminus onwards according to amino acid sequence): PH1: N-terminal PH domain; RBD: RAS-binding domain; PDZ: PSD-95/DlgA/ZO-1 domain; DH: DBL homology domain/RHOGEF domain and PH2: C-terminal PH domain. Locations of the 2 intronic variants are represented by dashed lines. Proteins reported to bind with certain regions of TIAM1 are indicated above the structure.