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Genotoxic agents (i.e., etoposide and cisplatin) could induce DNA damage, while PI3K inhibitor (i.e., BEZ235) blocked PI3K/mTOR pathway and induced caspase-3 activity. With the combination of genotoxic agents and BEZ235, the synergistic effect could further up-regulate the HM-1 apoptosis. The drug combination of genotoxic agents and BEZ235 might be a novel therapeutic option for NECC patients.
