Table 1. Correlation between MIC1 serum level and clinicopathological variables of lung cancer.
| Training set | Validation set | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variables | N | min | max | Median | Mean | IQR | P | N | min | max | Median | Mean | IQR | P |
| TNM stage | ||||||||||||||
| stage I | 95 | 319.3 | 3618.0 | 1274.5 | 1348.3 | 766.3 | 0.042 | 123 | 195.2 | 5759.0 | 1245.4 | 1359.6 | 757.2 | 0.017 |
| stage II | 60 | 347.8 | 2465.9 | 1222.0 | 1249.5 | 731.5 | 76 | 397.5 | 4272.7 | 1355.0 | 1556.1 | 940.1 | ||
| stage III | 100 | 396.6 | 5060.1 | 1365.9 | 1551.8 | 792.2 | 112 | 269.2 | 4493.4 | 1317.2 | 1454.6 | 810.0 | ||
| stage IV | 95 | 196.6 | 5292.4 | 1384.9 | 1600.4 | 644.0 | 100 | 126.0 | 5506.1 | 1477.8 | 1849.6 | 852.7 | ||
| T classification | ||||||||||||||
| T1-2 | 226 | 317.3 | 5292.4 | 1272.3 | 1342.2 | 686.3 | 0.0004 | 279 | 195.2 | 5759.0 | 1324.5 | 1493.2 | 787.6 | 0.35 |
| T3-4 | 116 | 196.6 | 5060.1 | 1470.0 | 1685.1 | 788.3 | 120 | 126.0 | 5277.8 | 1405.5 | 1580.2 | 833.2 | ||
| Unkown | 8 | 12 | ||||||||||||
| N classification | ||||||||||||||
| N0 | 115 | 319.3 | 3770.2 | 1294.9 | 1395.0 | 760.3 | 0.87 | 161 | 195.2 | 5759.0 | 1245.4 | 1380.0 | 743.2 | 0.182 |
| N1-3 | 224 | 196.6 | 5292.4 | 1326.1 | 1471.7 | 726.3 | 233 | 126.0 | 5506.1 | 1384.0 | 1590.6 | 838.1 | ||
| Unkown | 11 | 18 | ||||||||||||
| Remote metastasis | ||||||||||||||
| M0 | 255 | 319.3 | 5060.1 | 1276.2 | 1405.1 | 742.1 | 0.039 | 311 | 126.0 | 5759.0 | 1315.9 | 1430.7 | 788.1 | 0.0006 |
| M1 | 95 | 196.6 | 5292.4 | 1395.6 | 1599.7 | 681.7 | 100 | 151.7 | 5506.1 | 1488.5 | 1884.2 | 858.8 | ||
| Differentiation | ||||||||||||||
| Poorly | 140 | 196.6 | 5292.4 | 1347.4 | 1522.7 | 713.1 | 0.072 | 181 | 126.0 | 5506.1 | 1465.0 | 1660.1 | 830.1 | 0.0001 |
| Moderately | 169 | 380.9 | 3773.7 | 1336.3 | 1439.6 | 694.8 | 161 | 269.2 | 5354.4 | 1310.9 | 1532.3 | 775.2 | ||
| Well | 41 | 352.5 | 5060.1 | 1006.9 | 1312.6 | 671.6 | 69 | 195.2 | 5759.1 | 1092.8 | 1249.3 | 800.6 | ||
| Pathological type | ||||||||||||||
| SCLC | 31 | 468.5 | 3680.0 | 1338.5 | 1500.4 | 725.7 | 0.953 | 40 | 126.0 | 4450.7 | 1401.7 | 1603.6 | 749.6 | 0.665 |
| NSCLC | 319 | 196.6 | 5292.4 | 1319.0 | 1453.8 | 731.7 | 371 | 151.7 | 5759.0 | 1365.6 | 1534.3 | 825.5 | ||
| Adenocarcinoma | 114 | 319.3 | 3773.7 | 1381.3 | 1471.8 | 723.3 | 0.182 | 114 | 151.7 | 4050.6 | 1369.7 | 1413.6 | 714.6 | 0.756 |
| Squamous cell carcinomas | 197 | 196.6 | 5292.4 | 1276.6 | 1441.7 | 725.4 | 247 | 195.2 | 5759.0 | 1347.8 | 1579.63 | 863.9 | ||
| others | 8 | 10 | ||||||||||||