Table 1. Selected top 10 altered expression of circRNAs in HSCC tissues by fold change (FC).

Top 10 upregulated circRNAs
CircRNA ID	FC	P value	Chromosome	Strand	Gene symbol	No. miRNA targets
hsa_circ_0024109	40.295	0.009	11	−	MMP1	12
hsa_circ_0058143	30.341	0.022	2	−	FN1	3
hsa_circ_0058104	27.735	0.003	2	−	FN1	6
hsa_circ_0058106	26.222	0.014	2	−	FN1	2
hsa_circ_0058121	25.540	0.018	2	−	FN1	4
hsa_circ_0058107	23.066	0.002	2	−	FN1	11
hsa_circ_0024108	22.409	0.007	11	−	MMP1	10
hsa_circ_0058095	22.185	0.004	2	−	FN1	21
hsa_circ_0058115	20.418	0.003	2	−	FN1	28
hsa_circ_0058097	20.418	0.004	2	−	FN1	159
Top 10 downregulated circRNAs
hsa_circ_0003441	23.548	0.007	13	+	TDRD3	0
hsa_circ_0001290	21.410	0.027	3	−	SETD2	0
hsa_circ_0050108	21.133	0.003	19	+	SSBP4	47
hsa_circ_0088635	20.274	0.005	9	+	GARNL3	0
hsa_circ_0002260	20.023	0.039	5	+	PAPD4	2
hsa_circ_0007646	19.457	0.031	4	+	DCUN1D4	0
hsa_circ_0082212	18.660	0.019	7	+	FLNC	73
hsa_circ_0001189	17.691	0.006	21	+	MORC3	3
hsa_circ_0036722	17.339	0.013	15	−	RHCG	24
hsa_circ_0087964	16.798	0.011	9	−	LPAR1	885

CircRNA ID was based on circBase (http://www.circbase.org/).