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The following abbreviations are used: PTEN, phosphatase and tensin homolog; PDK1, 3-phosphoinositide dependent kinase 1; TSC1/2, tuberous sclerosis complex proteins 1 and 2; Pheb, Ras homolog enriched in brain; S6K1, ribosomal protein S6 kinase 1; BAD, BCL-2-associated death promoter; IKKs, IκB kinases; CREB, cyclic AMP response element binding protein.
