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. 2017 May 2;8(28):45496–45505. doi: 10.18632/oncotarget.17569

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Copyright: © 2017 Zhang et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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(A) Schematic representation of the location of miR-874 in chr5:136983261-136983338. Three CpG sites(cg19032799, cg04184179, cg03894789 ), located on chromosome chr5:136983354, chr5: 136983367 and chr5: 136983373, represented as yellow spot located in the promoter region of miR-874. (B) The methylation level for three CpG sites (cg19032799, cg04184179, cg03894789) in breast cancer tissues compared with para-normal tissues from external breast cancer cohort in TCGA database. (C) miR-874 expression negatively correlated with against the DNA methylation levels of its 300-upstream region (spearmanr = −0.321, P value < 0.01) depicted MethHC (http://MethHC.mbc.nctu.edu.tw).