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. 2017 Apr 19;8(28):45506–45516. doi: 10.18632/oncotarget.17221

Figure 1. Development of anti-C5 antibody targeting MG4 domain.

Figure 1

(A) 3-D structure of C5 (Reference PDB 3CU7). MG4 domain and binding epitope of anti-C5 antibody were identified in green and red, respectively. (B) Schematic diagram of mouse C5 with anti-C5 antibody. (C) Western blot analyses of serum of DBA/1 mouse with anti-C5 antibody in non-reducing and reducing conditions. Representative figures from 3 independent experiments. (D) Binding affinity of anti-C5 antibody to MG4 domain and β-chain of mouse C5 on ELISA (n = 6).