Experimental scheme depicts about ethanol extract of N. oceanica treatment and LPS injection (A). To investigate effect of ethanol extract of N. oceanica in LPS-induced memory impairment, we performed a water maze test (B, C), probe test (D) and step-through type passive avoidance test (E). Memory function was determined by the escape latencies (B, sec) and distance (C, cm) for 5 days, and time spent in target quadrant (D, %) in the probe test after administration of LPS. Each value is mean ± S.D. from 8 mice. *, Significantly different from control group (p < 0.05). #, Significantly different from LPS-treated group (p < 0.05).