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. 2017 Apr 21;8(28):45643–45655. doi: 10.18632/oncotarget.17314

Figure 10. Proposed mechanisms by which ubenimex contributes to JQ1 sensitivity by pushing the equilibrium between the positive regulation of pTEFb by Brd4 and its negative regulation by HEXIM1 towards to pTEFb inactive via regulating autophagy and AKT.

Figure 10

→, positive regulation or activation; ┴, negative regulation or blockade.