Figure 3. Annexin V-PI staining assessing U87M mock control and U87M HEXIM1 knockdown cells’ apoptosis rates after JQ1 or JQ1 combined ubenimex treatment.

JQ1 induced apoptosis in U87M cells, the effect attenuated by the downregulation of HEXIM1, indicating the role of HEXIM1 on JQ1 sensitivity. Ubenimex enhanced both mock control and HEXIM1 knockdown cells' JQ1 sensitivity. (A) Flow-cytograms; (B) quantitation of a (*P < 0.05).