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. 2017 Apr 21;8(28):45643–45655. doi: 10.18632/oncotarget.17314

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Copyright: © 2017 Han et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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(A) Subcutaneous injection of 5×106 U251 or T98G cells per nude mouse was carried out. At 2 weeks (set as day 0), treatment was initiated and tumor lengths and widths were measured every 7 days. Tumor volume was derived as length × width 2/2. JQ1 at 30 mg/kg daily inhibited tumor growth; Combine with ubenimex significantly enhanced JQ1 efficiency. (B) HEXIM1 IHC staining was carried out, data showed HEXIM1 expression significantly improved after JQ1+Ubenimex treatment. (C) Quantitation of B (*P < 0.05 vs control).