Figure 2. HSP70 inhibitors alter mitochondrial membrane potential.
(A-B) Mitochondrial membrane potential was measured in the cell lines indicated (H1299 lung cancer and melanomas A875, WM88, WM852, WM793, WM3000). Cells were treated with PES, PET-16, G-TPP or structurally related control compounds (TPPO and Cyclo-225). Results shown are the mean ± SD of at least three independent experiments relative to control (DMSO-treated) cells.