Table 2. Univariate and multivariate Cox proportional hazards analyses for disease-free survival and overall survival.
| Disease-Free Survival | Overall Survival | |||
|---|---|---|---|---|
| HR (95%CI) | P Value | HR (95%CI) | P Value | |
| Univariate | ||||
| Nrf2–NQO1 | 1.439 (1.079–1.920) | 0.013 | 1.410 (1.096–1.814) | 0.007 |
| Age (y) | 0.999 (0.653–1.529) | 0.996 | 1.378 (0.955–1.990) | 0.085 |
| Gender | 0.867 (0.508–1.478) | 0.595 | 0.628 (0.380–1.039) | 0.056 |
| Histopathology | 1.429 (0.981–2.081) | 0.063 | 1.113 (0.801–1.546) | 0.525 |
| Lymph node metastasis | 1.751 (1.125–2.727) | 0.013 | 2.175 (1.462–3.237) | 0.000 |
| TNM stage | 1.926 (1.251–2.963) | 0.003 | 2.543 (1.761–3.673) | 0.000 |
| Grade group | 1.231 (0.786–1.927) | 0.364 | 1.227 (0.835–1.804) | 0.297 |
| Smoking history | 0.867 (0.523–1.438) | 0.580 | 1.196 (0.752–1.902) | 0.441 |
| Multivariate | ||||
| Nrf2–NQO1 | 1.393 (1.033–1.879) | 0.030 | 1.364 (1.053–1.767) | 0.019 |
| Lymph node metastases | 1.176 (0.680–2.033) | 0.563 | 1.285 (0.786–2.100) | 0.318 |
| TNM stage | 1.738 (1.032–2.928) | 0.038 | 2.209 (1.412–3.457) | 0.001 |
CI: confidence interval. Log-rank test was used to evaluate the statistical significance of variables in survival distribution. Multivariate analysis was performed by use of the Cox proportional hazard regression analysis.