Table 5. The cut-offs of APRI and FIB-4 for significant fibrosis and cirrhosis in patients≥30 years.

Score	Classification	Cut-offs	Sensitivity, %	Specificity,%	PPV,%	NPV, %
APRI	Significant fibrosis	0.4*	91	24	42	81
		1.2**	32	90	66	69
	Cirrhosis	0.5*	91	36	18	96
		1.5**	32	90	33	90
FIB-4	Significant fibrosis	0.8*	90	20	41	77
		2.1**	31	90	66	68
	Cirrhosis	1.2*	91	32	17	96
		2.6**	35	90	35	90

APRI, aspartate transaminase to platelet ratio index; FIB-4, fibrosis index based on the 4 factors; PPV, positive predictive value; NPV, negative predictive value; Cut-offs* were established by obtaining a sensitivity of at least 90%; Cut-offs** were established by obtaining a specificity of at least 90%.