Table 6. The cut-offs of APRI and FIB-4 for significant fibrosis and cirrhosis in patients < 30 years.

Score	Classification	Cut-offs	Sensitivity, %	Specificity,%	PPV,%	NPV, %
APRI	Significant fibrosis	0.2*	94	15	21	91
		1.0**	18	91	31	83
	Cirrhosis	0.3*	91	16	5	98
		1.2**	10	90	4	96
FIB-4	Significant fibrosis	0.5*	90	15	20	86
		1.2**	20	90	32	83
	Cirrhosis	0.8*	91	14	5	97
		1.4**	10	92	5	96

APRI, aspartate transaminase to platelet ratio index; FIB-4, fibrosis index based on the 4 factors; PPV, positive predictive value; NPV, negative predictive value; Cut-offs* were established by obtaining a sensitivity of at least 90%; Cut-offs** were established by obtaining a specificity of at least 90%.