Table 5. Pre-experimental analysis of the differential expression of 10 selected circulating plasma microRNAs in EGFR exon 19 deletion versus EGFR wild-type NSCLC patients.

MicroRNA	Fold-changea	Regulation	p-value
miR-19a-3p	4.1	N/A	0.070
miR-20a-5p	5.7	N/A	0.052
miR-21-5p	4.8	N/A	0.107
miR-24-3p	4.0	N/A	0.119
miR-25-3p	5.7	N/A	0.052
miR-30d-5p	4.1	N/A	0.098
miR-107	14.5	Up	0.002*
miR-122	6.3	Up	0.005*
miR-125a-5p	6.6	Up	0.017*
miR-195	9.0	Down	0.002*

* p < 0.05

^aCalculated using the equation 2^{−Δ (ΔCt)}, where Δ(ΔCt) = (Ct_miR – Ct_5SrRNA)_EGFR-MUT(+) – (Ct_miR – Ct_5SrRNA)_EGFR-WT

Abbreviations: N/A, not applicable.