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. 2017 Apr 25;8(28):45807–45824. doi: 10.18632/oncotarget.17416

Table 7. Measures of the diagnostic potential of the differentiation of NSCLC patients with EGFR exon 19 deletion (EGFR19DEL) or EGFR p.L858R mutations (EGFRp.L858R) versus EGFR wild-type (EGFRWT) patients.

Variable EGFR19DEL vs. EGFRWT EGFRp.L858R vs. EGFRWT
miR-107 miR-195 miR-107 + miR-195 miR-107 miR-122 miR-107 + miR-122
AUC 0.72 0.75 0.74 0.77 0.75 0.78
Sensitivity 64.7% 71.8% 71.7% 64.2% 73.6% 67.1%
Specificity 76.6% 69.1% 78.9% 80.6% 63.9% 82.5%
Cutoff 0.097 0.876 −0.057 0.153 0.124 0.321
PPV 82.1% 79.0% 91.4% 80.0% 83.7% 81.8%
NPV 76.8% 80.3% 80.3% 89.8% 86.9% 88.3%

Abbreviations: PPV, positive predictive value; NPV, negative predictive value.