Table 7. Measures of the diagnostic potential of the differentiation of NSCLC patients with EGFR exon 19 deletion (EGFR19DEL) or EGFR p.L858R mutations (EGFRp.L858R) versus EGFR wild-type (EGFRWT) patients.
Variable | EGFR19DEL vs. EGFRWT | EGFRp.L858R vs. EGFRWT | ||||
---|---|---|---|---|---|---|
miR-107 | miR-195 | miR-107 + miR-195 | miR-107 | miR-122 | miR-107 + miR-122 | |
AUC | 0.72 | 0.75 | 0.74 | 0.77 | 0.75 | 0.78 |
Sensitivity | 64.7% | 71.8% | 71.7% | 64.2% | 73.6% | 67.1% |
Specificity | 76.6% | 69.1% | 78.9% | 80.6% | 63.9% | 82.5% |
Cutoff | 0.097 | 0.876 | −0.057 | 0.153 | 0.124 | 0.321 |
PPV | 82.1% | 79.0% | 91.4% | 80.0% | 83.7% | 81.8% |
NPV | 76.8% | 80.3% | 80.3% | 89.8% | 86.9% | 88.3% |
Abbreviations: PPV, positive predictive value; NPV, negative predictive value.