Table 4A. ORR.
| Marker | ORR (%) | Odds ratio (95% CI) | p-value |
|---|---|---|---|
| All patients | 18 | ||
| KRAS wt vs mut* | 22 vs 14 | 1.7 (0.2-10.6) | 0.43 |
| BRAF wt vs mut# | 19 vs 0 | 0.7 (0.1-8.2) | 0.54 |
| pERK1/2T202/Y204 < median vs > median | 29 vs 6 | 6.8 (0.7-63.1) | 0.07 |
| pAKTS473 0+/1+ vs 2+/3+ | 31 vs 5 | 8.7 (0.9-81.9) | 0.04 |
| pp70S6K1T389 < median vs > median | 23 vs 11 | 2.5 (0.4-14.8) | 0.27 |
| KRAS wt/BRAF wt andpERK1/2T202/Y204 < median vs > median | 40 vs 14 | 4.0 (0.3-40.1) | 0.25 |
| KRAS mut* or BRAF mut# andpERK1/2T202/Y204 < median vs > median | 22 vs 0 | 2.1 (1.2-3.7) | 0.16 |
| KRAS wt/BRAF wt andpAKTS473 0+/1+ vs 2+/3+ | 40 vs 14 | 4.0 (0.3-47.1) | 0.25 |
| KRAS mut* or BRAF mut# andpAKTS473 0+/1+ vs 2+/3+ | 33 vs 0 | 3.8 (1.6-8.7) | 0.04 |
| KRAS wt/BRAF wt andpp70S6K1T389 < median vs > median | 43 vs 20 | 3.0 (0.3-25.9) | 0.31 |
| KRAS mut* or BRAF mut# andpp70S6K1T389 < median vs > median | 17 vs 0 | 1.5 (1.0-2.1) | 0.33 |
*exon 2; #exon 15.