Table 4B. PFS.
| Marker | Median PFS (months) | HR (95% CI) | p-value(log rank) |
|---|---|---|---|
| All patients | 3.5 | ||
| KRAS wt vs mut* | 3.5 vs 4.0 | 0.8 (0.4-1.6) | 0.58 |
| BRAF wt vs mut# | 3.5 vs 1.4 | 4.2 (1.1-15.7) | 0.03 |
| pERK1/2T202/Y204 < median vs > median | 4.0 vs 3.1 | 1.8 (0.9-3.6) | 0.09 |
| pAKTS473 0+/1+ vs 2+/3+ | 3.5 vs 4.1 | 0.7 (0.4-1.4) | 0.32 |
| pp70S6K1T389 < median vs > median | 3.5 vs 3.7 | 0.9 (0.5-1.8) | 0.91 |
| KRAS wt/BRAF wt andpERK1/2T202/Y204 < median vs > median | 3.6 vs 3.0 | 1.9 (0.7-5.5) | 0.22 |
| KRAS mut* or BRAF mut# andpERK1/2T202/Y204 < median vs > median | 4.0 vs 2.5 | 1.7 (0.6-4.7) | 0.31 |
| KRAS wt/BRAF wt andpAKTS473 0+/1+ vs 2+/3+ | 3.0 vs 5.0 | 0.9 (0.3-2.4) | 0.76 |
| KRAS mut* or BRAF mut# andpAKTS473 0+/1+ vs 2+/3+ | 4.0 vs 3.3 | 0.8 (0.3-2.4) | 0.67 |
| KRAS wt/BRAF wt andpp70S6K1T389 < median vs > median | 3.5 vs 4.1 | 1.0 (0.4-2.7) | 0.97 |
| KRAS mut* or BRAF mut# andpp70S6K1T389 <median vs > median | 3.5 vs 2.8 | 0.9 (0.3-2.8) | 0.89 |
*exon 2; #exon 15.