Table 4C. OS.
| Marker | Median OS (months) | HR (95% CI) | p-value(log rank) |
|---|---|---|---|
| All patients | 11.1 | ||
| KRAS wt vs mut* | 11.3 vs 10.6 | 0.8 (0.4-1.6) | 0.55 |
| BRAF wt vs mut# | 10.2 vs 10.8 | 1.5 (0.5-5.2) | 0.51 |
| pERK1/2T202/Y204 < median vs > median | 13.0 vs 9.8 | 2.7 (1.3-5.6) | <0.01 |
| pAKTS473 0+/1+ vs 2+/3+ | 12.2 vs 10.4 | 1.5 (0.8-2.9) | 0.22 |
| pp70S6K1T389 < median vs > median | 11.1 vs 10.4 | 1.2 (0.6-2.3) | 0.52 |
| KRAS wt/BRAF wt andpERK1/2T202/Y204 < median vs > median | 19.6 vs 6.1 | 4.2 (1.2-15.1) | 0.02 |
| KRAS mut* or BRAF mut# andpERK1/2T202/Y204 < median vs > median | 11.5 vs 7.8 | 3.2 (1.0-9.9) | 0.03 |
| KRAS wt/BRAF wt andpAKTS473 0+/1+ vs 2+/3+ | 14.7 vs 9.5 | 2.0 (0.7-6.0) | 0.20 |
| KRAS mut* or BRAF mut# andpAKTS473 0+/1+ vs 2+/3+ | 10.2 vs 10.8 | 1.0 (0.4-2.8) | 0.97 |
| KRAS wt/BRAF wt andpp70S6K1T389 < median vs > median | 19.6 vs 9.5 | 1.4 (0.5-4.0) | 0.50 |
| KRAS mut* or BRAF mut# andpp70S6K1T389 < median vs > median | 10.8 vs 7.8 | 1.9 (0.6-5.9) | 0.25 |
*exon 2; #exon 15.