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. 2017 May 2;8(28):46090–46103. doi: 10.18632/oncotarget.17552

Figure 4. Silencing of HOXA-AS2 expression suppresses tumor growth and inhibits Ki-67 expression in vivo.

Figure 4

(A) Silencing of HOXA-AS2 expression reduced the tumor volume. Athymic mice were injected with MCF-7 cells transfected with control or HOXA-AS2 siRNAs. Tumor volume was measured at 0, 7, 14, 21, 28 and 35 days (*P < 0.05). (B) Photographs of representative tumors in nude mice were obtained five weeks after injection. (C) The tumor weight was calculated (*P < 0.05). (D) The expression level of HOXA-AS2 was detected by qRT-PCR in tissues (*P < 0.05). (E, F) The protein expression level of Ki-67 was analyzed by immunohistochemical assays (*P < 0.05).