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. 2017 May 2;8(28):46145–46162. doi: 10.18632/oncotarget.17574

Table 2. The gene list for the differentially expressed genes of cervical cancer (CxCa-DEGs) and the cervical cancer signature (CxCa-Sig).

CxCa-DEGs CxCa-Sig
Upregulated genes AURKA, BIRC5, BUB1, CDC20, CDC45, CDK1, CDKN2A, CENPA, CKS1B, CKS2, DNMT1, GINS2, HLTF, KIF11, KIF23, KIF2C, MCM5, MCM6, NDC80, NEK2, NUSAP1, PLAU, POLE2, PRC1, RAD51AP1, RFC4, RFC5, SMC4, STMN1, SYCP2, TACC3, TIMELESS, TK1, TOP2A, TOPBP1, TPX2, TTK, TYMS (38 genes) AURKA, BIRC5, BUB1, CDC20, CDC45, CDK1, CDKN2A, CENPA, CKS1B, CKS2, GINS2, KIF11, KIF23, KIF2C, MCM5, MCM6, NDC80, NEK2, POLE2, PRC1, RFC4, RFC5, SMC4, STMN1, TACC3, TIMELESS, TK1, TOP2A, TOPBP1, TPX2, TTK, TYMS (32 genes)
Downregulated genes CDA, CFD, CRNN, EDN3, ENDOU, GSTA4, LDOC1, PDGFD, PPP1R3C, UPK1A (10 genes) CDA (1 gene)

CxCa-DEGs represented the overlapped DEGs from 7 microarray data sets. The network of CxCa-DEGs was reconstructed by the STRING database. The genes directly linked to each other were used as a CxCa-Sig for further analyses.