. 2017 May 8;8(28):46262–46272. doi: 10.18632/oncotarget.17694

Table 1. Summary of SUDV disease in mice, guinea pigs, ferrets, NHPs and humans.

References		Knockout mice (wild-type)	Guinea pigs (GPA)	Ferrets (wild-type)	Ferrets (wild-type)	NHPs (wild-type)	Humans (wild-type)
References		[16]	[5]	Current study	[13]	[17]	[18] [19]
Fever		Yes	Yes	Yes	Yes	Yes	Yes
Weight loss / weakness		Yes	Yes	Yes	Yes	Yes	Yes
Leukopenia		Yes	Yes	Yes	Yes	Yes	Yes
Platelet count		Decrease	Decrease	Decrease	Decrease	Decrease	Decrease
Dyspnea / hypoxemia		N/A	N/A	N/A	N/A	Yes	Yes
Heart rate		N/A	N/A	N/A	N/A	Increase
Rash		N/A	No	No	Yes	Sometimes	Yes
Gastrointestinal symptoms		N/A	N/A	N/A	N/A	Yes	Yes
Neurologic complications		N/A	N/A	N/A	N/A	N/A	Yes
External hemorrhage		No	No	No	No	No	Yes
Coagulopathy		Yes	Yes	Yes	Yes	N/A	Yes
Changes in serum levels	Albumin	N/A	Decrease	Decrease	Decrease	Decrease
	Alkaline phosphatase	N/A	Increase	Increase	Increase	Increase / No change
	Alanine transaminase	Increase	No change	Increase	N/A	Increase
	Aspartate transaminase	Increase	N/A	Increase	Increase	Increase
	Amylase	no change	N/A	Increase	Increase	Decrease
	Total bilirubin	N/A	N/A	Increase / no change	N/A	Increase / no change
	Blood urea nitrogen	no change	Increase	Increase / no change	Increase	Increase
	Creatinine	N/A	no change	no change	Increase	Increase / no change
	GGT	N/A	N/A	N/A	Increase	Increase / no change
	Calcium	N/A	Decrease	Decrease	N/A	Decrease
	Glucose	N/A	N/A	Increase	N/A	N/A
	Sodium	N/A	N/A	Decrease / no change	N/A	N/A
	Potassium	N/A	N/A	Increase / no change	N/A	N/A
	Phosphorus	N/A	no change	Increase / no change	N/A	N/A
	Total protein	N/A	Decrease	Decrease	no change	Decrease / no change
Dysregulated cytokines	TNF-alpha	N/A	N/A	N/A	Increase	N/A	Yes
Dysregulated cytokines	Nitric oxide	N/A	N/A	N/A	Increase	N/A	Yes