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. 2017 May 19;8(28):46286–46297. doi: 10.18632/oncotarget.18000

Figure 2. The effect of the DNMT antagonist RG108 on acute seizure behavior.

Figure 2

(A) After pretreatment with RG108 (RG group), seizure latency was slightly increased in KA-treated mice compared with the SE group (each group, n = 13). (B) After pretreatment with RG108 (n = 12), the cumulative duration of seizures (≥ grade 3) was significantly shortened. *P < 0.05, compared with the SE group (n = 13). (C) After pretreatment with RG108 (n = 12), the Racine score (seizure severity) was reduced in KA-treated mice, especially the rate of grade 5 seizures and status epilepticus. *P < 0.05, compared with the SE group. (n = 13).