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. 2017 May 19;8(28):46286–46297. doi: 10.18632/oncotarget.18000

Figure 5. The effect of RG108 pretreatment on RASgrf1 expression at different time points after the onset of epileptic seizures.

Figure 5

Representative PCR and western blot show the hippocampus of the control group (KA-, RG108-), KA-treated(SE) group (KA+, RG108-) and RG108-pretreated (RG) group prior to KA (KA+, RG108+). (A, D) A representative PCR and western blot show RASgrf1 mRNA and protein expression in the hippocampus of the control group (lane 1), SE group (lanes 3, 5 and 7) and RG group (lanes 2, 4 and 6) at different time points. (B, E) Quantitative analyses show that the mRNA and protein expression of RASgrf1 decreased gradually after the onset of epileptic seizures and that a significant difference appeared on the 45th day. *P < 0.05, compared with the control group. (C, F) Pretreatment with RG108 reversed the decrease in RASgrf1 mRNA and protein expression, as shown 45 days after the onset of epileptic seizures, #P < 0.05 (each group n = 5).