Table 3. Pooled changes of blood pressure and related intermediate phenotypes between carriers of the 64Trp/64Trp and 64Trp/64Arg genotypes.
| Phenotypes | Groups | Studies (N) | WMD | 95% CI | P | I2 |
|---|---|---|---|---|---|---|
| SBP (mmHg) | All studies | 16 | 1.67 | −0.48 ∼ 3.82 | 0.128 | 80.7% |
| Studies in hypertensives | 6 | 0.87 | 0.39 ∼ 1.35 | < 0.001 | 0.0% | |
| DBP (mmHg) | All studies | 16 | 0.29 | −0.28 ∼ 0.87 | 0.317 | 15.3% |
| Studies in hypertensives | 6 | 0.88 | 0.59 ∼ 1.17 | < 0.001 | 0.0% | |
| BMI (kg/m2) | All studies | 14 | −0.06 | −0.59 ∼ 0.48 | 0.838 | 83.4% |
| Studies in hypertensives | 5 | −0.70 | −1.24 ∼ -0.17 | 0.010 | 42.1% | |
| FBG (mmol/L) | All studies | 6 | 0.01 | −0.06 ∼ 0.07 | 0.835 | 0.0% |
| Studies in hypertensives | 3 | 0.03 | −0.08 ∼ 0.15 | 0.574 | 12.0% | |
| Fasting insulin (pmol/L) | All studies | 11 | −0.94 | −7.00 ∼ 5.12 | 0.762 | 71.1% |
| Studies in hypertensives | 3 | −2.07 | −11.54 ∼ 7.39 | 0.668 | 0.0% | |
| Total cholesterol (mmol/L) | All studies | 12 | −0.03 | −0.12 ∼ 0.05 | 0.433 | 49.9% |
| Studies in hypertensives | 4 | 0.00 | −0.04 ∼ 0.04 | 0.891 | 2.8% | |
| HDLC (mmol/L) | All studies | 9 | −0.01 | −0.06 ∼ 0.03 | 0.580 | 64.9% |
| Studies in hypertensives | 4 | −0.01 | −0.08 ∼ 0.07 | 0.879 | 50.7% |
Abbreviations: WMD, weighted mean difference; 95% CI, 95% confidence interval; SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; FBG, fasting blood glucose; HDLC, high-density lipoprotein cholesterol.