Table 1. demonstrates the detailed process of articles identification and selection.
| Author | Published year | Region | Number (male/female) |
Age mean±SD/ median (range) |
Follow up(m) mean±SD/ median (range) |
Tumor site | Number LVI+ (%) | nCRT | pCRT | TNM stage | Outcome | SQa |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ghosh | 2016 | Australia | 690(393/297) | NR | 53.5(34-65) | C | 209(30.3) | NR | NR | II | DFS | 5 |
| Nikberg | 2016 | Sweden | 2649(NA) | NA | NA | R | 387(14.6) | P | P | II | DFS | NA |
| Zhang | 2016 | China | 333(188/145) | 63(17-86) | 52.23±29.7 | C | 40(12.0) | N | P | II | OS | 8 |
| Peng | 2014 | Australia | 458(252/206) | 73(23-97) | 62.4(1.3-126) | C | 115(25.1) | N | P | II | OS | 8 |
| Patel | 2014 | US | 175(95/80) | 65(24-89) | 720 | R | 24(13.7) | N | N | I | OS | 6 |
| Du | 2014 | China | 145(84/61) | 69(21-82) | 68.5(6-120) | C | 10(6.9) | N | N | I/II | DFS | 8 |
| Lin | 2014 | Taiwan | 962(612/350) | 71.8(24-107) | 60.2(4-106) | CR | 50(5.2) | N | N | II | DFS | 7 |
| Artac | 2014 | Turkey | 554(332/222) | 62(26-88) | NR | C | 107(19.3) | N | P | II | DFS | 7 |
| Venook | 2013 | US | 690(360/330) | NR | NR | C | 78(11.3) | NR | P | II | DFS | 5 |
| Betge | 2012 | Austria | 120(61/59) | 71.2(33.4-85.2) | 83(1-180) | CR | 26(21.7) | N | NR | II | OS/DFS | 7 |
| Barresi | 2012 | Italy | 82(45/37) | 70(48-89) | NR | CR | 23(28.0) | N | N | I | OS | 5 |
| Choi | 2010 | Hong Kong | 664(385/279) | 70(27-96) | 44(12-104) | CR | 88(13.3) | NR | P | II | DFS | 7 |
| Lim | 2010 | Korea | 903(NR) | NR | 87.5(3-120) | CR | 95(10.5) | N | P | II | OS/DFS | 6 |
| Huh | 2010 | Korea | 341(209/132) | 63.1(22-85) | 57.6(0.4-106.2) | CR | 44(12.9) | N | P | II | DFS | 6 |
| Lin CC | 2009 | Taiwan | 375(274/101) | 68.3±12.1 | 48.5(0.7-96.6) | C | 22(5.9) | NR | P | II | DFS | 7 |
| Earle | 2009 | US | 258(139/119) | NR | NR | C | 63(24.4) | N | P | II | OS | 6 |
| Lee | 2006 | Korea | 121(89/32) | 57.7(28-80) | NR | CR | 25(12.9) | NR | P | I/II | DFS | 6 |
| Law | 2005 | Hong Kong | 224(141/83) | 69(27-89) | NR | R | 29(12.9) | NR | NR | II | OS/DFS | 6 |
| Lennon | 2003 | US | 137(79/39) | 70(36-90) | 72(36-108) | C | 34(24.8) | NR | NR | II | OS | 4 |
AJCC American Joint Committee on Cancer, R rectum, C colon, CR colorectum, DFS disease-free survival, N none of patients accept the therapy, nCRT neoadjuvant chemoradiotherapy, NR not reported, NA not access, OS overall survival, P part of patients accept the therapy, pCRT postoperative chemoradiotherapy, LVI+ the colorectal cancer patient with lymphovascular invasion positive, SD standard deviation, SQ score of study quality,
a Study quality was judged based on the Newcastle-Ottawa Scale