Table 2. Characteristics of studies and different miRs expression related to DFS in GIC patients.

References	Year	MiRNAs	Nations	Number	DFS		Cut-off	Detection	Sample	Follow
		(n=15)		(n=1373)	HR*	95% CI	value	methods	types	up
#Diaz [60]	2008	miR-106a↓	Spain	CRC 110	2.80	1.30-60	median	RT-PCR	tissue	68-99
Nguyen [67]	2010	miR-375↓	USA	EC 58	2.73*	1.17-6.39	median	RT-PCR	tissue	<80
#Hu [28]	2011	miR-30e↑	China	EC 158	1.67	1.17-2.38	median	RT-PCR	tissue	1-256
#Ayerbes [18]	2012	miR-200c↑	Spain	GC 52	2.27*	1.09-4.71	mean	RT-PCR	blood	6-53
#Inoue [23]	2012	miR-107↑	Japan	GC 161	0.14*	0.01-0.67	mean	RT-PCR	tissue	6-72
Nie [68]	2012	miR-365↓	China	CRC 76	1.84	0.80-4.22	mean	RT-PCR	tissue	1-38
#Tang [42]	2013	miR-200b↓	China	GC 36	1.57	0.97-2.53	2 fold	ISH	tissue	23-59
#Fu [21]	2014	miR-222↑	China	GC 114	3.38*	1.87-5.23	median	RT-PCR	plasma	18-60
#Lin [34]	2014	miR-508↑	China	EC 207	3.92	2.68-5.75	median	RT-PCR	tissue	<60
#Sun [35]	2014	miR-195↓	China	EC 98	5.59	1.13-11.16	median	RT-PCR	tissue	1-63
Sun [69]	2014	miR-338-3p↓	China	CRC 40	2.30	1.20-3.90	mean	RT-PCR	tissue	1-72
#Imaoka [19]	2015	miR-203↓	Japan	GC 130	1.54	0.46-5.13	YI	RT-PCR	serum	1-78
Zhou [70]	2015	miR-200c↓	China	GC 63	1.38	0.70-2.72	median	RT-PCR	tissue	28-33
		miR-141↓			1.20	0.58-2.46	median	RT-PCR	tissue	28-33
Yue [71]	2015	miR-106a-5p↑	China	CRC 70	2.21	1.46-4.11	median	RT-PCR	tissue	<80

# = Studies included both OS and DFS; * = adjusted HR;↑or↓ up-regulated or down-regulated with poor prognosis; GIC gastrointestinal cancer; EC esophageal cancer; GC gastric cancer; CRC colorectal cancer; OS overall survival; DFS disease free survival; HR hazard ratio; YI Youden index; RT-PCR reverse transcription PCR; ISH in sit hybridization; Calculated HR of DFS was in bold.