Table 3. miRs and target genes in gastrointestinal cancer.

MiRs (n=35)	Poor prognosis	Role	Target genes	Function	Reference
miR-21↑	Up-regulation	oncogene	PTEN, TIMP1	growth/invasion/migration/apoptosis	[16, 24–27]
miR-107↑	Up-regulation	oncogene	DICER1	invasion/migration	[23]
miR-377↑	Up-regulation	oncogene	P53, PTEN, TIMP1	proliferation	[10]
miR-25↑	Up-regulation	oncogene	FBXW7	growth/invasion/migration	[55]
miR-106b↑	Up-regulation	oncogene	PTEN	invasion/migration	[47]
miR-500↑	Up-regulation	oncogene	NF-ĸB	proliferation/apoptosis	[51]
miR-181a↑	Up-regulation	oncogene	PTEN	proliferation	[61]
miR-183↑	Up-regulation	oncogene	PTEN	migration	[62]
miR-508↑	Up-regulation	oncogene	INPP5J	growth/invasion/migration	[34]
miR-942↑	Up-regulation	oncogene	sFRP4, GSK3β, TLE1	growth	[37]
miR-1288↑	Up-regulation	oncogene	FOXO1	proliferation	[66]
miR-137↓	Down-regulation	suppressor	AKT2	growth	[22]
miR-138↓	Down-regulation	suppressor	NF-kB	growth	[31]
miR-760↓	Down-regulation	suppressor	HIST1H3D	migration	[40]
miR-326↓	Down-regulation	suppressor	FSCN1	growth/migration	[53]
miR-125a-5p↓	Down-regulation	suppressor	ERBB2	growth	[39]
miR-134a↓	Down-regulation	suppressor	FSCN, MMP14	invasion/migration	[33]
miR-150↓	Down-regulation	suppressor	ZEB1	EMT	[30]
miR-217↓	Down-regulation	suppressor	EZH2	progression/metastasis	[48]
miR-506↓	Down-regulation	suppressor	Yap1	proliferation/invasion	[52]
miR-26a↓	Down-regulation	suppressor	FGF9	growth/metastasis	[41]
miR-200b↓	Down-regulation	suppressor	DNMT3A/3B, SP1	growth	[42]
miR-23b-3p↓	Down-regulation	suppressor	ATG12, HMGB2	chemoresistance	[12]
miR-133↓	Down-regulation	suppressor	CDC42–PAK	growth/migration/invasion	[48]
miR-185↓	Down-regulation	suppressor	DNMT1, CDC42	metastasis	[43]
miR-194↓	Down-regulation	suppressor	RBX1	proliferation/migration	[56]
miR-218↓	Down-regulation	suppressor	Robo1	growth/invasion/apoptosis	[49]
miR-200c/141↓	Down-regulation	suppressor	ZEB1/2	migration/ invasion	[70]
miR-143↓	Down-regulation	suppressor	TLR2	invasion/migration	[11]
miR-106a↓	Down-regulation	suppressor	EGFL7, E2F1	invasion/migration	[60]
miR-365↓	Down-regulation	suppressor	Cyclin D1, Bcl-2	apoptosis	[68]
miR-16↓	Down-regulation	suppressor	P53	growth	[64]
miR-338-3p↓	Down-regulation	suppressor	SMO	apoptosis	[69]
miR-203↓	Down-regulation	suppressor	E-cadherin	EMT/migration	[19]