Table 3. Toxicity: comparison between the two studies included in the meta-analysis.

	PROMID [18]		CLARINET [19]
Drug-related adverse events	SSA (n = 42)	Placebo (n = 43)	SSA (n = 101)	Placebo (n = 103)
Death, n (%)	0 (0)	0 (0)	0 (0)	0 (0)
Total number, n (%)	-	-	50 (49.5)	29 (28.1)
SAE, n (%)	11 (26.2)	10 (23.2)	3 (2.9)	1 (0.9)
Severe, n (%)	19 (45.2)	11 (25.6)	26 (25.7)	32 (31.1)
Treatments discontinuation, n (%)	5 (11.9)	0 (0)	1 (0.9)	0 (0)
Biliary stones, n (%)	5 (11.9)	1 (2.3)	10 (9.9)	3 (2.9)

Abbreviations: SSA: Somatostatin Analog; SAE: Serious Adverse Events