Fig 8. Summary of irisin effect on cardiac function and regulation of muscular proteins in zebrafish.

Scheme depicting the role of irisin on cardiovascular physiology, and in the regulation of muscle proteins in zebrafish. Irisin is abundantly expressed in cardiac and skeletal muscles, and has a positive role on cardiac functions (indicated by upward arrow), and muscular proteins in zebrafish. Knockdown of irisin played an important role in modulating muscle protein encoding mRNAs and cardiovascular physiology in zebrafish (indicated by down arrow). Together, irisin is a positive modulator of cardiac physiology and regulates muscle proteins in zebrafish.