Skip to main content
. 2017 Aug 3;12(8):e0181738. doi: 10.1371/journal.pone.0181738

Fig 3. Vaccination with mosaic H5 MVA stimulates neutralizing and HI antibodies against H5N1 only.

Fig 3

HI antibody titer was determined using a standard HI assay against both H1N1pdm A/California/04/2009 and H5N1 A/Vietnam/1203/2004. HI antibodies against H1N1pdm were undetectable until 30 days after challenge (A). HI antibodies against H5N1 were detected as early as 7 days after prime (B). Neutralization against the challenge H1N1pdm A/California/04/2009 virus was measured using plaque reduction neutralization test, where neutralization was only detected 14 days post challenge (C). Data points represent individual monkeys and report the IgG concentration where a 50% reduction in plaque formation is observed, bars indicate geometric mean and error bars indicated the 95% confidence interval of the geometric mean.