Table 4. Module assignment and relevant functions of the 20 genes.
| Gene | Module ID | Relevant Function |
|---|---|---|
| EPSTI1 | 3.1 | IFN signaling |
| HERC5 | 3.1 | IFN signaling |
| IFI27 | IFN signaling | |
| IFI44 | 3.1 | IFN signaling |
| IFI44L | 3.1 | IFN signaling |
| IFIT3 | 3.1 | IFN signaling |
| IFITM3 | 3.1 | IFN signaling |
| ISG15 | IFN signaling | |
| LY6E | 3.1 | IFN signaling/immune regulator |
| RSAD2 | 3.1 | IFN dependent and independent response |
| TLR5 | Bind to flagellin/activate NFKb pathway | |
| ANXA3 | 2.2 | Calcium and phospholipid |
| ARG1 | 2.2 | ARG metabolism/immune response |
| FCGR1A | phagocytosis | |
| FCGR1B | phagocytosis | |
| HP | 2.2 | Antioxidant activity / binding to free Hb |
| IL18R1 | IL signaling | |
| LCN2 | 2.2 | Stabilize MMP9/bind to ferric siderophore |
| MMP9 | 2.2 | Matrix degradation |
| S100A12 | 3.3 | Bing to RAGE/activate NFKb/inhibit MMP9 |