Table 4. List of differentially downregulated genes in the soleus muscle of exercised C57BL/6 PAD mice.
| Gene Symbol | FC | Gene Symbol | FC | Gene Symbol | FC |
|---|---|---|---|---|---|
| Chga | -41.09 | Ror2 | -2.80 | Gdf11 | -1.97 |
| Wnt16 | -29.94 | Fam83g | -2.79 | Sulf1 | -1.97 |
| Dlk1 | -26.98 | Cd109 | -2.79 | Adcy7 | -1.96 |
| Tnn | -24.17 | Cpxm1 | -2.78 | 2610203C20Rik | -1.96 |
| Rspo2 | -23.43 | Sntb1 | -2.77 | Has2 | -1.95 |
| Prr32 | -16.48 | Prc1 | -2.76 | Sytl2 | -1.95 |
| Rtl1 | -15.48 | Enpp1 | -2.74 | Vgll3 | -1.94 |
| Lgr5 | -15.05 | Col6a3 | -2.73 | Scd2 | -1.93 |
| Arhgap36 | -14.34 | Slc37a2 | -2.67 | Il1rl2 | -1.93 |
| Krt8 | -14.31 | Rbp4 | -2.67 | BC023105 | -1.93 |
| Mmp12 | -12.99 | Avpr1a | -2.67 | Pthlh | -1.92 |
| Dcx | -12.88 | Csrp2 | -2.67 | Fam114a1 | -1.92 |
| Cldn2 | -12.21 | Ccl21a | -2.66 | Rbp1 | -1.91 |
| Krt18 | -11.56 | Dkk3 | -2.62 | Klhl13 | -1.91 |
| Lrrc15 | -11.08 | Pcdhgb1 | -2.62 | Myo5a | -1.91 |
| Mest | -10.79 | Peg3 | -2.61 | Arnt2 | -1.91 |
| C1qtnf3 | -10.05 | Ephb3 | -2.60 | Itga11 | -1.90 |
| Nrk | -10.04 | Adamts20 | -2.60 | Mfap5 | -1.90 |
| Mirg | -9.65 | Rnasel | -2.60 | Frzb | -1.90 |
| Rian | -9.25 | Il20rb | -2.59 | Rab31 | -1.90 |
| Meg3 | -8.99 | Basp1 | -2.59 | Col24a1 | -1.90 |
| Dsp | -8.96 | Mfsd7a | -2.58 | Rbms3 | -1.90 |
| Ptn | -8.85 | Gldn | -2.58 | Cdkn1a | -1.89 |
| Ripply1 | -8.82 | E2f1 | -2.56 | Tfpi | -1.89 |
| AW551984 | -7.95 | Cercam | -2.54 | Bex1 | -1.89 |
| Myh4 | -7.67 | Tnfrsf11a | -2.54 | Sorbs2 | -1.86 |
| Actc1 | -7.54 | Gamt | -2.53 | Mtcp1 | -1.86 |
| Tro | -7.47 | Ptprf | -2.53 | Igtp | -1.85 |
| Myl4 | -7.16 | Mdga1 | -2.52 | Mrc1 | -1.85 |
| Peg10 | -7.01 | Itga9 | -2.51 | Boc | -1.84 |
| Atp6v0d2 | -6.96 | Thbs2 | -2.50 | Mir99ahg | -1.84 |
| Fbn2 | -6.82 | Prkag3 | -2.50 | Npas2 | -1.84 |
| Postn | -6.60 | Nr5a2 | -2.47 | Sfn | -1.84 |
| Slc6a19 | -6.55 | Ccdc141 | -2.47 | Serf1 | -1.84 |
| Th | -6.51 | Efs | -2.45 | Gbp5 | -1.84 |
| Msln | -6.23 | Kcnc4 | -2.45 | Gpc3 | -1.84 |
| Mybph | -6.21 | Tdrd9 | -2.43 | Olfr558 | -1.83 |
| Spon1 | -5.74 | Bid | -2.42 | Arhgap22 | -1.83 |
| Myh3 | -5.67 | Serpinb6b | -2.41 | Dlg4 | -1.83 |
| Slfn4 | -5.34 | Vcan | -2.40 | Lepre1 | -1.82 |
| Aldh3a1 | -5.25 | Adamts7 | -2.40 | Arhgap32 | -1.81 |
| Plagl1 | -5.09 | Fndc1 | -2.39 | Sh3tc1 | -1.81 |
| Fjx1 | -4.99 | Srpx2 | -2.37 | Armcx6 | -1.80 |
| Klf14 | -4.92 | Igf1 | -2.37 | Selp | -1.80 |
| Cthrc1 | -4.89 | Atp1b2 | -2.36 | Plat | -1.80 |
| Gdnf | -4.83 | Gatm | -2.36 | Dupd1 | -1.80 |
| Grem2 | -4.78 | Eda2r | -2.36 | Tnfaip3 | -1.79 |
| Glipr1 | -4.64 | Usp18 | -2.36 | Klhdc8b | -1.78 |
| Gpr65 | -4.59 | Tubb6 | -2.35 | Bicc1 | -1.78 |
| Zfp365 | -4.38 | Ddah1 | -2.35 | Rap2b | -1.77 |
| Tnnt2 | -4.34 | Orai2 | -2.34 | Irf8 | -1.77 |
| 6330403K07Rik | -4.33 | Pi15 | -2.33 | Klf10 | -1.77 |
| Sprn | -4.26 | Tnfrsf23 | -2.33 | Mustn1 | -1.76 |
| Adamts16 | -4.26 | Emilin1 | -2.33 | Vav3 | -1.76 |
| Igfn1 | -4.22 | Chst2 | -2.33 | Birc3 | -1.76 |
| Lair1 | -4.22 | Itga4 | -2.32 | 9430073C21Rik | -1.76 |
| Tnc | -4.19 | Nhs | -2.32 | Nabp1 | -1.75 |
| Cemip | -4.06 | Fbln7 | -2.30 | Morc4 | -1.75 |
| Begain | -3.97 | Kcnq1ot1 | -2.30 | Rcn1 | -1.75 |
| Ddc | -3.95 | Fam109b | -2.30 | Sh3bp1 | -1.75 |
| Pmp2 | -3.90 | Parm1 | -2.29 | Zfp948 | -1.75 |
| A930003A15Rik | -3.89 | Anxa8 | -2.28 | Ttyh2 | -1.74 |
| Scn5a | -3.88 | Lhfpl2 | -2.28 | Zc2hc1a | -1.74 |
| Oasl1 | -3.87 | Rtp4 | -2.27 | 4933439C10Rik | -1.74 |
| Prnd | -3.81 | Sulf2 | -2.26 | Gpx7 | -1.73 |
| Col12a1 | -3.76 | Ccbe1 | -2.26 | Efemp2 | -1.72 |
| Kcnk1 | -3.74 | Lyve1 | -2.26 | Fkbp14 | -1.72 |
| Slfn8 | -3.71 | Adamts3 | -2.25 | Pycr1 | -1.71 |
| Fam65c | -3.69 | Ogn | -2.24 | G0s2 | -1.71 |
| Mss51 | -3.68 | Osr2 | -2.24 | Rsad2 | -1.71 |
| Ankrd1 | -3.64 | Lsp1 | -2.24 | Stk17b | -1.71 |
| Ifit3 | -3.54 | Primpol | -2.22 | Junb | -1.70 |
| Xlr3b | -3.53 | Vash2 | -2.22 | Malat1 | -1.70 |
| Dnm3os | -3.51 | Traf4 | -2.21 | Htra1 | -1.69 |
| Map3k7cl | -3.50 | Fat1 | -2.21 | Camk2d | -1.69 |
| Ifit1 | -3.45 | A930004D18Rik | -2.21 | Mob3c | -1.69 |
| Apol9b | -3.42 | Igsf3 | -2.20 | Sdc2 | -1.68 |
| Fibin | -3.42 | Mndal | -2.20 | Man1a | -1.68 |
| Nov | -3.41 | Msc | -2.17 | Igsf1 | -1.68 |
| Tceal7 | -3.39 | Ankrd35 | -2.17 | Angptl2 | -1.66 |
| Piezo2 | -3.37 | Igfbp4 | -2.16 | Col5a3 | -1.66 |
| Zim1 | -3.36 | Trp63 | -2.16 | Atp10a | -1.66 |
| Ccna2 | -3.33 | Plekha7 | -2.16 | Rin2 | -1.66 |
| Cpne2 | -3.31 | Gpr64 | -2.16 | Numbl | -1.66 |
| Lox | -3.31 | Rgs10 | -2.15 | Daam2 | -1.65 |
| Fcgr1 | -3.30 | Elovl6 | -2.14 | Tnfsf10 | -1.65 |
| Dclk1 | -3.30 | Rcor2 | -2.14 | Chst12 | -1.65 |
| Cx3cr1 | -3.29 | Tnfrsf22 | -2.14 | Nes | -1.65 |
| Pvalb | -3.27 | Ckap4 | -2.14 | Dab2 | -1.64 |
| Pamr1 | -3.19 | Fap | -2.14 | Ext1 | -1.63 |
| Actn3 | -3.17 | Matn2 | -2.12 | Mdm4 | -1.63 |
| Gadd45a | -3.16 | Cd44 | -2.12 | Kdelc2 | -1.62 |
| Plod2 | -3.12 | Pdk3 | -2.11 | Chpf2 | -1.62 |
| Rec8 | -3.10 | Mrc2 | -2.10 | Tspan9 | -1.62 |
| Capn6 | -3.09 | Galnt16 | -2.10 | Ccdc102a | -1.62 |
| Aspn | -3.08 | Mybpc2 | -2.10 | Scai | -1.61 |
| Zap70 | -3.07 | Tas1r1 | -2.10 | AI480526 | -1.60 |
| Hmcn1 | -3.06 | Cdr2l | -2.09 | Sesn2 | -1.59 |
| I830012O16Rik | -3.06 | Entpd7 | -2.09 | Gprc5c | -1.59 |
| Oasl2 | -3.02 | Slc25a24 | -2.08 | Fam65b | -1.59 |
| Oas1a | -3.01 | Zfp760 | -2.08 | Fndc3b | -1.59 |
| Col5a2 | -3.00 | Tmsb10 | -2.07 | Atp13a3 | -1.59 |
| Ptch2 | -3.00 | Sertad4 | -2.07 | Zfp503 | -1.57 |
| Col7a1 | -2.97 | Abi3bp | -2.06 | C130074G19Rik | -1.56 |
| Alx4 | -2.96 | Ifi203 | -2.06 | Aebp1 | -1.56 |
| Myog | -2.96 | Fbxl22 | -2.06 | Tanc2 | -1.56 |
| Lrrc55 | -2.96 | Loxl1 | -2.04 | Sort1 | -1.56 |
| C1ql3 | -2.96 | Myod1 | -2.04 | Ift122 | -1.55 |
| Sfrp2 | -2.95 | Spred3 | -2.04 | Ppp1r3d | -1.55 |
| Mex3a | -2.93 | Dse | -2.03 | Fmr1 | -1.55 |
| Cacnb3 | -2.92 | S100a4 | -2.02 | Iffo1 | -1.55 |
| Mmp3 | -2.92 | Cdkn1c | -2.01 | Ctsz | -1.54 |
| Ryr3 | -2.92 | Lgals3bp | -2.01 | Pear1 | -1.52 |
| Mstn | -2.91 | Atp1b4 | -2.01 | Ttc14 | -1.52 |
| Mmp23 | -2.90 | Zfp354c | -2.00 | Mid1 | -1.52 |
| Gxylt2 | -2.90 | Mafa | -2.00 | Tmem44 | -1.52 |
| Wisp1 | -2.89 | Adam19 | -2.00 | Mtap | -1.52 |
| Marcksl1 | -2.88 | Gk5 | -2.00 | Lgals1 | -1.52 |
| Trim46 | -2.87 | Bbc3 | -1.99 | Txndc5 | -1.51 |
| D430019H16Rik | -2.85 | Hps1 | -1.98 | Dusp6 | -1.51 |
| Foxd3 | -2.82 | Pcdh18 | -1.97 | Creb3l2 | -1.50 |
FC, fold change.
Sedentary PAD mice (n = 4) and exercised PAD mice (n = 4). Differentially downregulated genes met an average FC criterion of <-1.5.