Fig 2. Mutating the tRNA-binding sites of Gcn2 abolishes activation in response to UVC irradiation.
A Alignment of the HisRS-like domain of budding yeast and fission yeast Gcn2. B The indicated strains were irradiated with 1100 J/m2 and samples were taken at the indicated times after irradiation. eIF2α phosphorylation was detected by immunoblotting, α-tubulin levels are shown to check even loading.