Table 1. Demographic data of patients with different sepsis syndromes (n = 42).
| Characteristic | Sepsis (n = 14) | Severe sepsis (n = 13) | Septic shock (n = 15) | p value |
|---|---|---|---|---|
| Gender (Male/Female) | 8/6 | 7/6 | 9/6 | 0.948 |
| Age | 4.9 (2.1–10.1) | 1.7 (0.2–3.6) | 6.8 (4.5–14.6) | 0.067 |
| Site of infection | - | |||
| Respiratory | 7 | 6 | 5 | |
| Central nervous system | 3 | 2 | 1 | |
| Cardiovascular | 1 | 0 | 3 | |
| Digestive | 2 | 0 | 0 | |
| Urinary | 0 | 1 | 1 | |
| Other/unknown | 1 | 4 | 5 | |
| Laboratory | ||||
| Defined pathogen | 9 | 6 | 7 | 0.550 |
| Organisms | - | |||
| Streptococcus pneumoniae | 7 | 6 | 5 | |
| Salmonella group B or D | 2 | 0 | 0 | |
| Escherichia coli | 0 | 0 | 1 | |
| Mycoplasma pneumoniae | 0 | 0 | 1 | |
| White blood count (103//μL) | 8.6 (5.5–12.9) | 7.3 (3.8–13.1) | 8.7 (2.6–12.5) | 0.969 |
| Hemoglobulin (mg/dL) | 13.1 (10.7–14.6) | 10.3 (9.1–11) | 12.2 (8.5–12.8) | 0.024* |
| Platelet (103/μL) | 209 (143–246) | 175 (38.5–410) | 161 (40–224) | 0.147 |
| Thrombomodulin (D1) (mU/ml) | 2.9 (1.8–4.7) | 3.3 (1.3–8.6) | 6.9 (5.8–12.8) | 0.001* |
| Thrombomodulin (D3) (mU/ml) | 3 (1.5–3.5) | 4.4 (0.5–6) | 5.8 (4.6–10.8) | 0.002* |
| Disease severity | ||||
| Mechanical ventilation | 0 | 4 | 15 | <0.001* |
| Use of vasopressor | 0 | 0 | 15 | <0.001* |
| PRISM-III score | 7 (5–9) | 13 (9–16) | 22 (19–45) | <0.001* |
| PELOD score | 10 (0–11) | 11 (2–12) | 31 (22–50) | <0.001* |
| P-MODS | 0 (0–1) | 1 (0–3) | 6 (3–9) | <0.001* |
| DIC score | 2 (0–2) | 3 (1–3) | 5 (3–5) | <0.001* |
| Outcome | ||||
| Mortality | 0 | 0 | 4 | 0.019* |
| ICU stay (days) | 5.5 (3–9) | 9 (7–15) | 9 (4–16) | 0.148 |
| Hospitalization (days) | 15 (9–21) | 16 (13–32) | 16 (11–29) | 0.663 |
Abbreviations: D1, day 1; D3, day 3; PRISM, Pediatric Risk of Mortality; PELOD, Pediatric Logistic Organ Dysfunction; P-MODS, Pediatric-Multiple Organ Dysfunction Score; DIC, disseminated intravascular coagulation; ICU, intensive care unit
*p<0.05, statistically significant