Table 1. Synergy testing of fluconazole (FLU) and FK506 against Candida parapsilosis species group and Lodderomyces elongisporus strains.
| Taxon Name | Reference no | Minimum inhibitory concentrations (MIC; μg/ml) | Fractional inhibitory Outcome concentration (FIC) Index |
||||
|---|---|---|---|---|---|---|---|
| Best Combined | |||||||
| FLU | FK506 | FLU | FK506 | ||||
| C.metapsilosis | CBS 2315 | 1 | >16 | 1 | 0.03125 | 1.0019 | Indifferent |
| CBS 107.47 | 1 | >16 | 1 | 0.125 | 1.007 | Indifferent | |
| CBS 109.07* | 4 | >16 | 1 | 2 | 0.375 | Synergy | |
| CBS 111.27 | 16 | >16 | 8 | 8 | 1 | Indifferent | |
| CBS 107.46 | 8 | >16 | 2 | 0.125 | 0.2578 | Synergy | |
| CBS 2916 | 16 | >16 | 16 | 8 | 1.5 | Indifferent | |
| C.orthopsilosis | CBS 107.41 | 1 | >16 | 1 | 0.03125 | 1.0019 | Indifferent |
| CBS 107.42 | 4 | >16 | 1 | 0.125 | 0.2578 | Synergy | |
| CBS 109.06* | 2 | >16 | 2 | 0.25 | 1.015 | Indifferent | |
| CBS 8825 | 1 | >16 | 2 | 0.125 | 2.0078 | Indifferent | |
| CBS 107.43 | 16 | >16 | 16 | 0.125 | 1.0078 | Indifferent | |
| CBS 9894 | 4 | >16 | 4 | 0.0625 | 1.0039 | Indifferent | |
| CBS 2212 | 8 | >16 | 4 | 0.125 | 0.5078 | Additive | |
| C.parapsilosis | CBS 8836 | 1 | >16 | 0.5 | 0.03125 | 0.5019 | Additive |
| CBS 7248 | 0.5 | >16 | 0.25 | 0.125 | 0.507 | Additive | |
| CBS 2915 | 1 | >16 | 2 | 0.15625 | 2.0098 | Indifferent | |
| CBS 604 | 4 | >16 | 2 | 0.03125 | 0.5019 | Additive | |
| CBS 2216 | 1 | >16 | 0.25 | 1 | 0.3125 | Synergy | |
| CBS 8181 | 4 | >16 | 1 | 0.03125 | 0.2519 | Synergy | |
| CBS 125.41 | 2 | >16 | 1 | 0.03125 | 0.5019 | Additive | |
| CBS 1954* | 4 | >16 | 2 | 0.03125 | 0.5019 | Additive | |
| L.elongisporus | 7660 | 1 | >16 | 0.5 | 0.03125 | 0.5019 | Additive |
| 7661 | 1 | >16 | 0.5 | 0.03125 | 0.5019 | Additive | |
| 7663 | 1 | >16 | 0.25 | 0.0625 | 0.2539 | Synergy | |
| 7665 | 1 | >16 | 1 | 0.0625 | 1.0039 | Indifferent | |
| 7666 | 1 | >16 | 0.5 | 4 | 0.75 | Additive | |
| 7668 | 1 | >16 | 0.5 | 0.03125 | 0.50195 | Additive | |
| 7669 | 1 | >16 | 1 | 0.015625 | 1.00098 | Indifferent | |
| 7670 | 2 | >16 | 0.5 | 0.0625 | 0.2539 | Synergy | |
| 7672 | 2 | >16 | 0.5 | 0.03125 | 0.2519 | Synergy | |
| 7673 | 2 | >16 | 0.25 | 4 | 0.375 | Synergy | |
| 7675 | 1 | >16 | 0.5 | 1 | 0.5625 | Additive | |
CBS, Centraalbureau voor Schimmelcultures.
*, Type strain.