| GSK2606414, GSK2656157 (Second generation PERK inhibitor) |
Inhibits PERK and eIF2α phosphorylation, ATF4 translation and CHOP mRNA expression |
(67, 68) |
| ONC201 |
Inhibits eIF2α |
(114) |
| Salicylaldimines, 3-methoxy-6-bromosalicylaldehyde |
Inhibits IRE1α activity |
(71) |
| 4μ8C |
Inhibits IRE1α activity |
(72) |
| MKC-3946 |
Inhibits IRE1α activity |
(73) |
| STF-083010 |
Inhibits IRE1α activity |
(74) |
| Toyocamycin |
Inhibits IRE1α activity |
(75) |
| N9-(3-(dimethylamino) propyl)-N3,N3,N6,N6-tetramethylacridine-3,6,9-triamine (3,6-DMAD) |
Inhibits IRE1α activity |
(76) |
| Hydroxy-aryl-aldehydes (HAA) |
Inhibits IRE1α activity |
(77) |
| MKC-3946 |
Inhibits IRE1α activity |
(73) |
| STF-083010 |
Inhibits IRE1α activity |
(78) |
| Irestatin |
Inhibits IRE1α activity |
(60) |
| Eeyarestatin I (EerI) |
ERAD inhibitor |
(80) |
| Versipelostatin; Epigallocatechin gallate |
Inhibition of GRP78 chaperone function compromises ER protein folding |
(82, 83) |
| MAb159, PAT-SM6 |
GRP78 inhibitors |
(88, 115) |
