Table 1.
Abscess induction by modified S. aureus CP8 polysaccharides
| Polysaccharide | No. of animals with abscesses/total challenged with
|
AD50, μg | P value | ||||
|---|---|---|---|---|---|---|---|
| 200 μg | 20 μg | 2 μg | 0.2 μg | 0.02 μg | |||
| CP8 | ND | 40/43 (93%) | 27/40 (68%) | 15/37 (41%) | 1/9 (11%) | 0.33 | — |
| CP5 | ND | 14/17 (82%) | 14/17 (82%) | 3/9 (33%) | ND | 0.30 | — |
| Teichoic acid | ND | 14/18 (78%) | 11/17 (65%) | 3/10 (30%) | ND | 0.88 | — |
| CP8 (N-acetylated) | 10/19 (53%) | 4/20 (20%) | 3/20 (15%) | ND | ND | 184 | <0.0001* |
| CP8 (reduced) | 3/10 (30%) | 3/10 (30%) | 2/9 (22%) | ND | ND | 240 | <0.0001* |
| CP8 (de-O-acetylated) | ND | 8/8 (100%) | 6/7 (86%) | 2/8 (25%) | ND | 0.25 | NS |
| CP8 (de-O-/N-acetylated) | 2/8 (25%) | 3/10 (30%) | 2/9 (22%) | ND | ND | 245 | <0.0001† |
NS, not significant. ND, not done.
*
Compared with CP8.
‡
Compared with de-O-acetylated CP8.