Table 3.
CP8-activated T cells can facilitate or protect against abscess formation
| Abscess induction
|
Abscess protection
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| T cell stimulus | T cell transfer | SCCA | No. rats with abscesses/total | P value* | T cell stimulus | T cell transfer | i.p. Challenge | No. rats with abscesses/total | P value |
| Medium | i.p. | + | 1/10 (10%) | — | Medium | i.c. | S. aureus/SCCA | 9/10 (90%) | — |
| CP8 | i.p. | − | 8/10 (80%) | <0.01 | CP8 | i.c. | S. aureus/SCCA | 2/10 (20%) | <0.01 |
| CP8 | i.p. | − | 0/10 (0%) | — | GBS type III | i.c. | S. aureus/SCCA | 9/10 (90%) | — |
| GBS type III | i.p. | + | 0/10 (0%) | — | |||||
*
Compared to respective medium control.